Duffy blood group and its relationship to malaria map

Duffy antigen system - Wikipedia

duffy blood group and its relationship to malaria map

The Duffy blood group antigen serves not only as blood group antigen, but also in heterozigosity in the FYA allele in others malaria endemic regions [7, 8], and. Relationship between Duffy blood groups genotypes and malaria infection in Background: The negative homozygous condition for the Duffy blood group . parasitaemia as a risk factor for symptomatic malaria in a cohort of Ugandan. As a background to discussing the Duffy antigen in relation to malaria, a brief . The extracellular regions of the kD Duffy binding protein of P vivax and the.

The binding site for chemokines, the binding site for P.


Getting down to malarial nuts and bolts: Conserved residues in the Plasmodium vivax Duffy-binding protein ligand domain are critical for erythrocyte receptor recognition. PMC ] [ PubMed: The Duffy blood groups, vivax malaria, and malaria selection in human populations: Speculations on the origins of Plasmodium vivax malaria.

Mohandas NNarla A. Blood group antigens in health and disease.

Duffy antigen system

Deletion of the murine Duffy gene Dfy reveals that the Duffy receptor is functionally redundant. Study of anti-Fya in five black Fy a-b- patients. Delayed hemolytic transfusion reaction due to anti-Fyb caused by a primary immune response: The second example of anti-Duffy5. Delayed haemolytic transfusion reaction due to simultaneous appearance of anti-Fya and Anti-Fy5.

Duffy Blood Group System and the malaria adaptation process in humans

Haemolytic disease of the fetus and newborn due to anti-Fy a and the potential clinical value of Duffy genotyping in pregnancies at risk. Babinszki ABerkowitz RL.

duffy blood group and its relationship to malaria map

Haemolytic disease of the newborn caused by anti-c, anti-E and anti-Fya antibodies: Weinstein LTaylor ES. Hemolytic disease of the neonate secondary to anti-Fya. Am J Obstet Gynecol.

Duffy Blood Group System and the malaria adaptation process in humans

Female alloimmunization with antibodies known to cause hemolytic disease. Pogo AOChaudhuri A.


The molecular genetics of blood group polymorphism. New genotypes in Fy a-b- individuals: Neither linkage nor association of the usual type was the basis, but rather a protection against malaria provided by both traits. Fy6 is related to susceptibility to invasion of red cells by P. The authors found a perfect match between results of serotyping and detection by molecular methods.

They suggested that this assay is particularly useful for rapid genotyping of fetal amniotic cells to identify pregnancies at risk for HDN due to maternal-fetal incompatibilities within the Duffy blood group system. Duffy and the locus for a form of hereditary cataract are closely linked. From extensive family studies, Robson et al.

duffy blood group and its relationship to malaria map

The Duffy type in the father and a normal son with the same transposition was Fy abwhile in the mother it was Fy b. In the proband with the duplication it was Fy bsuggesting that the Duffy locus is situated at 1q2. The demonstration of close linkage to alpha-spectrin SPTA1; suggests the location of Fy in the q21 band Raeymaekers et al.

Fy a-b- Phenotype The Fy a-b- phenotype is rare among white and Asian populations, whereas it is the predominant phenotype among populations of black people, especially those originating in West Africa. The Fy a-b- phenotype provides complete protection from Plasmodium vivax infection see The Duffy gene from a very rare Caucasian individual AZ with the Fy a-b- phenotype had a bp deletion Fy bwk Phenotype Tournamille et al. An earlier suspicion of localization to chromosome 16 Crawford et al.

From study of a family with a pericentric inversion of chromosome 1, Lee et al.